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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
30/10/2019 |
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Data da última atualização: |
30/10/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
JOAQUIM, L. B.; CHUD, T. C. S.; MARCHESI, J. A. P.; SAVEGNAGO, R. P.; BUZANKAS, M. E.; ZANELLA, R.; CANTAO, M. E.; PEIXOTO, J. de O.; LEDUR, M. C.; IRGANG, R.; MUNARI, D. P. |
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Afiliação: |
LETÍCIA BORGES JOAQUIM, UNESP/Jaboticabal; TATIANE CRISTINA SELEGUIM CHUD, UNESP/Jaboticabal; JORGE AUGUSTO PETROLLI MARCHESI, UNESP/Jaboticabal; RODRIGO PELICIONI SAVEGNAGO, UNESP/Jaboticabal; MARCOS ELI BUZANSKAS, UFPB; RICARDO ZANELLA, UPF; MAURICIO EGIDIO CANTAO, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MONICA CORREA LEDUR, CNPSA; RENATO IRGANG, UFSC; DANÍSIO PRADO MUNARI, UNESP/Jaboticabal. |
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Título: |
Genomic structure of a crossbred landrace pig population. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Plos One, v. 14, n.2, e0212266, 2019. |
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DOI: |
10.1371/journal.pone.0212266 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Single nucleotide polymorphism (SNP) markers are used to study population structure and conservation genetics, which permits assessing similarities regarding the linkage disequilibrium and information about the relationship among individuals. To investigate the population genomic structure of 300 females and 25 males from a commercial maternal pig line we analyzed linkage disequilibrium extent, inbreeding coefficients using genomic and conventional pedigree data, and population stratification. The average linkage disequilibrium (r2 ) was 0.291 ± 0.312 for all adjacent SNPs, distancing less than 100 Kb (kilobase) between markers. The average inbreeding coefficients obtained from runs of homozygosity (ROH) and pedigree analyses were 0.119 and 0.0001, respectively. Low correlation was observed between the inbreeding coefficients possibly as a result of genetic recombination effect accounted for the ROH estimates or caused by pedigree identification errors. A large number of long ROHs might indicate recent inbreeding events in the studied population. A total of 36 homozygous segments were found in more than 30% of the population and these ROH harbor genes associated with reproductive traits. The population stratification analysis indicated that this population was possibly originated from two distinct populations, which is a result from crossings between the eastern and western breeds used in the formation of the line. Our findings provide support to understand the genetic structure of swine populations and may assist breeding companies to avoid a high level of inbreeding coefficients to maintain genetic diversity, showing the effectiveness of using genomewide SNP information for quantifying inbreeding when the pedigree was incomplete or incorrect. MenosAbstract: Single nucleotide polymorphism (SNP) markers are used to study population structure and conservation genetics, which permits assessing similarities regarding the linkage disequilibrium and information about the relationship among individuals. To investigate the population genomic structure of 300 females and 25 males from a commercial maternal pig line we analyzed linkage disequilibrium extent, inbreeding coefficients using genomic and conventional pedigree data, and population stratification. The average linkage disequilibrium (r2 ) was 0.291 ± 0.312 for all adjacent SNPs, distancing less than 100 Kb (kilobase) between markers. The average inbreeding coefficients obtained from runs of homozygosity (ROH) and pedigree analyses were 0.119 and 0.0001, respectively. Low correlation was observed between the inbreeding coefficients possibly as a result of genetic recombination effect accounted for the ROH estimates or caused by pedigree identification errors. A large number of long ROHs might indicate recent inbreeding events in the studied population. A total of 36 homozygous segments were found in more than 30% of the population and these ROH harbor genes associated with reproductive traits. The population stratification analysis indicated that this population was possibly originated from two distinct populations, which is a result from crossings between the eastern and western breeds used in the formation of the line. Our findings provide support to understand the gen... Mostrar Tudo |
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Palavras-Chave: |
SNP. |
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Thesagro: |
Genética; Marcador Genético; Polimorfismo Genético; Suíno. |
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Thesaurus Nal: |
Genetic markers; Genomics; Polymorphism; Swine. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02737naa a2200361 a 4500
001 2113663
005 2019-10-30
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1371/journal.pone.0212266$2DOI
100 1 $aJOAQUIM, L. B.
245 $aGenomic structure of a crossbred landrace pig population.$h[electronic resource]
260 $c2019
520 $aAbstract: Single nucleotide polymorphism (SNP) markers are used to study population structure and conservation genetics, which permits assessing similarities regarding the linkage disequilibrium and information about the relationship among individuals. To investigate the population genomic structure of 300 females and 25 males from a commercial maternal pig line we analyzed linkage disequilibrium extent, inbreeding coefficients using genomic and conventional pedigree data, and population stratification. The average linkage disequilibrium (r2 ) was 0.291 ± 0.312 for all adjacent SNPs, distancing less than 100 Kb (kilobase) between markers. The average inbreeding coefficients obtained from runs of homozygosity (ROH) and pedigree analyses were 0.119 and 0.0001, respectively. Low correlation was observed between the inbreeding coefficients possibly as a result of genetic recombination effect accounted for the ROH estimates or caused by pedigree identification errors. A large number of long ROHs might indicate recent inbreeding events in the studied population. A total of 36 homozygous segments were found in more than 30% of the population and these ROH harbor genes associated with reproductive traits. The population stratification analysis indicated that this population was possibly originated from two distinct populations, which is a result from crossings between the eastern and western breeds used in the formation of the line. Our findings provide support to understand the genetic structure of swine populations and may assist breeding companies to avoid a high level of inbreeding coefficients to maintain genetic diversity, showing the effectiveness of using genomewide SNP information for quantifying inbreeding when the pedigree was incomplete or incorrect.
650 $aGenetic markers
650 $aGenomics
650 $aPolymorphism
650 $aSwine
650 $aGenética
650 $aMarcador Genético
650 $aPolimorfismo Genético
650 $aSuíno
653 $aSNP
700 1 $aCHUD, T. C. S.
700 1 $aMARCHESI, J. A. P.
700 1 $aSAVEGNAGO, R. P.
700 1 $aBUZANKAS, M. E.
700 1 $aZANELLA, R.
700 1 $aCANTAO, M. E.
700 1 $aPEIXOTO, J. de O.
700 1 $aLEDUR, M. C.
700 1 $aIRGANG, R.
700 1 $aMUNARI, D. P.
773 $tPlos One$gv. 14, n.2, e0212266, 2019.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
24/10/2018 |
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Data da última atualização: |
24/10/2018 |
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Autoria: |
ULIAN, C. M. V.; LOURENÇO, M. L. G.; INAMASSU, L. R.; SOUZA, P. M.; MAMPRIM, M. J.; ALFONSO, A.; CHIACCHIO, S. B. |
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Afiliação: |
Carla Maria V. Ulian, Faculdade Pio Décimo; Maria Lucia G. Lourenço, Departamento de Clínica Veterinária/Faculdade de Medicina Veterinária e Zootecnia/Universidade Estadual Paulista - Unesp; Leticia R. Inamassu, Departamento de Reprodução Animal e Radiologia Veterinária/Faculdade de Medicina Veterinária e Zootecnia/Unesp; Priscilla M. Souza, Escola de Medicina Veterinária e Zootecnia/Universidade Federal do Tocantins; Maria Jaqueline Mamprim, Departamento de Reprodução Animal e Radiologia Veterinária/Faculdade de Medicina Veterinária e Zootecnia/Unesp; Angélica Alfonso, Departamento de Clínica Veterinária/Faculdade de Medicina Veterinária e Zootecnia/Universidade Estadual Paulista - Unesp; Simone B. Chiacchio, Departamento de Clínica Veterinária/Faculdade de Medicina Veterinária e Zootecnia/Universidade Estadual Paulista - Unesp. |
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Título: |
Echocardiographic parameters and vertebral heart size (VHS) in lambs during the neonatal period. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 9, p. 1869-1877, setembro 2018 |
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Idioma: |
Inglês |
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Notas: |
Título em português: Parâmetros ecocardiográficos e tamanho cardíaco vertebral (VHS) em cordeiros durante o período neonatal. |
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Conteúdo: |
Due to cardiac immaturity, newborns have a different morphology and cardiac output when compared with adults. The purpose of this study was to describe the cardiac changes in echocardiographic characteristics and vertebral heart size (VHS) in newborn lambs during the neonatal period. Twenty-eight healthy Ile de France lambs were evaluated from birth to 35 days old. With the assistance of echocardiography, this study evaluated, both in systole and diastole, indexes related to the right and left ventricles, the aorta (Ao), the left atrium (LA), the E point to septal separation (EPSS) and the thickness of the interventricular septum (VSd, VSs). The left atrium-to-aorta ratio (LA:Ao) was analyzed and both the shortening (SF%) and ejection fractions were calculated (EF%). The VHS was obtained by measuring the heart?s long and short axes and comparing it to the thoracic vertebrae. Throughout the first 35 days, the results obtained demonstrated an increased LV:RV ratio when compared to adult lambs. The calculated indexes and the LA:Ao ratio did not present statistically significant differences. The VHS values were normally distributed, presenting a mean of 9.67 vertebrae (v) during the entire period. Both radiographic and echocardiographic parameters showed significant differences between the analyzed moments. The VHS values ranged from 8.4v at the minimum end to 11.2v at the maximum. In order to prevent these changes from being misdiagnosed as heart diseases, this study contributed to take note of neonatal physiological anatomy peculiarities and in addition, it describes the parameters for this age in Ilê de France lambs. MenosDue to cardiac immaturity, newborns have a different morphology and cardiac output when compared with adults. The purpose of this study was to describe the cardiac changes in echocardiographic characteristics and vertebral heart size (VHS) in newborn lambs during the neonatal period. Twenty-eight healthy Ile de France lambs were evaluated from birth to 35 days old. With the assistance of echocardiography, this study evaluated, both in systole and diastole, indexes related to the right and left ventricles, the aorta (Ao), the left atrium (LA), the E point to septal separation (EPSS) and the thickness of the interventricular septum (VSd, VSs). The left atrium-to-aorta ratio (LA:Ao) was analyzed and both the shortening (SF%) and ejection fractions were calculated (EF%). The VHS was obtained by measuring the heart?s long and short axes and comparing it to the thoracic vertebrae. Throughout the first 35 days, the results obtained demonstrated an increased LV:RV ratio when compared to adult lambs. The calculated indexes and the LA:Ao ratio did not present statistically significant differences. The VHS values were normally distributed, presenting a mean of 9.67 vertebrae (v) during the entire period. Both radiographic and echocardiographic parameters showed significant differences between the analyzed moments. The VHS values ranged from 8.4v at the minimum end to 11.2v at the maximum. In order to prevent these changes from being misdiagnosed as heart diseases, this study contribute... Mostrar Tudo |
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Palavras-Chave: |
Cardiac silhouette; Ecocardiografia; Exame radiográfico; Neonatal; Radiographic examination; Silhueta cardíaca; Sistema cardiovascular; Vertebral heart size. |
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Thesagro: |
Ovino. |
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Thesaurus NAL: |
Cardiovascular system; Echocardiography; Sheep. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/185063/1/Echocardiographic-parameters-and-vertebral.pdf
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Marc: |
LEADER 02811naa a2200349 a 4500
001 2098149
005 2018-10-24
008 2018 bl uuuu u00u1 u #d
100 1 $aULIAN, C. M. V.
245 $aEchocardiographic parameters and vertebral heart size (VHS) in lambs during the neonatal period.$h[electronic resource]
260 $c2018
500 $aTítulo em português: Parâmetros ecocardiográficos e tamanho cardíaco vertebral (VHS) em cordeiros durante o período neonatal.
520 $aDue to cardiac immaturity, newborns have a different morphology and cardiac output when compared with adults. The purpose of this study was to describe the cardiac changes in echocardiographic characteristics and vertebral heart size (VHS) in newborn lambs during the neonatal period. Twenty-eight healthy Ile de France lambs were evaluated from birth to 35 days old. With the assistance of echocardiography, this study evaluated, both in systole and diastole, indexes related to the right and left ventricles, the aorta (Ao), the left atrium (LA), the E point to septal separation (EPSS) and the thickness of the interventricular septum (VSd, VSs). The left atrium-to-aorta ratio (LA:Ao) was analyzed and both the shortening (SF%) and ejection fractions were calculated (EF%). The VHS was obtained by measuring the heart?s long and short axes and comparing it to the thoracic vertebrae. Throughout the first 35 days, the results obtained demonstrated an increased LV:RV ratio when compared to adult lambs. The calculated indexes and the LA:Ao ratio did not present statistically significant differences. The VHS values were normally distributed, presenting a mean of 9.67 vertebrae (v) during the entire period. Both radiographic and echocardiographic parameters showed significant differences between the analyzed moments. The VHS values ranged from 8.4v at the minimum end to 11.2v at the maximum. In order to prevent these changes from being misdiagnosed as heart diseases, this study contributed to take note of neonatal physiological anatomy peculiarities and in addition, it describes the parameters for this age in Ilê de France lambs.
650 $aCardiovascular system
650 $aEchocardiography
650 $aSheep
650 $aOvino
653 $aCardiac silhouette
653 $aEcocardiografia
653 $aExame radiográfico
653 $aNeonatal
653 $aRadiographic examination
653 $aSilhueta cardíaca
653 $aSistema cardiovascular
653 $aVertebral heart size
700 1 $aLOURENÇO, M. L. G.
700 1 $aINAMASSU, L. R.
700 1 $aSOUZA, P. M.
700 1 $aMAMPRIM, M. J.
700 1 $aALFONSO, A.
700 1 $aCHIACCHIO, S. B.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 38, n. 9, p. 1869-1877, setembro 2018
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