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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
20/03/2018 |
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Data da última atualização: |
20/03/2018 |
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Autoria: |
MAGALHÃES, L. F.; MAGALHÃES, G. M.; CALAZANS, S. G.; CRIVELLENTI, L. Z.; LIMA, G. P.; MEDEIROS-RONCHI, A. A. |
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Afiliação: |
Larissa Fernandes Magalhães, Departamento de Patologia Animal/Universidade Federal de Uberlândia - UFU; Geórgia Modé Magalhães, Departamento de Patologia Animal/Instituto Federal Sul de Minas; Sabryna Gouveia Calazans, Departamento de Patologia Animal/Universidade de Franca - Unifran; Leandro Zuccolloto Crivellenti, Departamento de Patologia Animal/Universidade de Franca - Unifran; Gabriela Piovan Lima, Departamento de Patologia Animal/Universidade de Franca - Unifran; Alessandra Aparecida Medeiros-Ronchi, Departamento de Patologia Animal/Universidade Federal de Uberlândia - UFU. |
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Título: |
Imunomarcação da transição epitélio-mesenquima na neoplasia mamária primária de cadelas e sua metástase em linfonodo. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 12, p. 1479-1482, dezembro 2017. |
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Idioma: |
Inglês |
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Notas: |
Título em inglês: Epithelial to mesenchymal transition immunostaining in canine primary mammary tumor and lymph node. |
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Conteúdo: |
Mammary carcinomas in dogs have a high metastatic capacity which gives a shorter survival rate for patients with this type of tumor. The epithelial-mesenchymal transition phenotype, characterized by the trade of intermediary filaments of cytokeratin by vimentin, also by the loss of the adhesion protein between cells (E-cadherin) is associated with metastasis. Due to this fact, it was aimed to evaluate, by immunostaining, the expression of vimentin, cytokeratin and E-cadherin in canine mammary tumors and the metastasis in lymph node, in order to assess the cell behavior when facing this cancer. Five cases of canine mammary tumors and metastasis in lymph node were evaluated. The averages of immunostainings of the group of primary neoplasms were compared with the averages of the lymph node group. The results showed that immunostaining for cytokeratins (p=0,1407) and E-caderina (p=0,312) were not significant between the groups, despite the expression mean of cadherin was higher in the metastase group. The expression of vimentin (p=0,04) was greater at sites of metastases. It is concluded that the expression of vimentin increases in the focus of the metastase in relation to their respective primary canine mammary tumors, characterizing cellular structural alteration, conferring a transient epithelial-mesenchymal phenotype. And cadherin present strong evidence of increased focus on metastasis characterizing increased adhesion. |
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Palavras-Chave: |
Invasão; Invasion; Linfonodo; Oncologia; Oncology. |
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Thesagro: |
Cão; Proteína; Tumor. |
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Thesaurus Nal: |
Dogs; Lymph nodes; Mammary neoplasms (animal); Proteins. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/174163/1/imunomarcacao-da-transicao-epitelio-mesenquima.pdf
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Marc: |
LEADER 02529naa a2200337 a 4500
001 2089386
005 2018-03-20
008 2017 bl uuuu u00u1 u #d
100 1 $aMAGALHÃES, L. F.
245 $aImunomarcação da transição epitélio-mesenquima na neoplasia mamária primária de cadelas e sua metástase em linfonodo.$h[electronic resource]
260 $c2017
500 $aTítulo em inglês: Epithelial to mesenchymal transition immunostaining in canine primary mammary tumor and lymph node.
520 $aMammary carcinomas in dogs have a high metastatic capacity which gives a shorter survival rate for patients with this type of tumor. The epithelial-mesenchymal transition phenotype, characterized by the trade of intermediary filaments of cytokeratin by vimentin, also by the loss of the adhesion protein between cells (E-cadherin) is associated with metastasis. Due to this fact, it was aimed to evaluate, by immunostaining, the expression of vimentin, cytokeratin and E-cadherin in canine mammary tumors and the metastasis in lymph node, in order to assess the cell behavior when facing this cancer. Five cases of canine mammary tumors and metastasis in lymph node were evaluated. The averages of immunostainings of the group of primary neoplasms were compared with the averages of the lymph node group. The results showed that immunostaining for cytokeratins (p=0,1407) and E-caderina (p=0,312) were not significant between the groups, despite the expression mean of cadherin was higher in the metastase group. The expression of vimentin (p=0,04) was greater at sites of metastases. It is concluded that the expression of vimentin increases in the focus of the metastase in relation to their respective primary canine mammary tumors, characterizing cellular structural alteration, conferring a transient epithelial-mesenchymal phenotype. And cadherin present strong evidence of increased focus on metastasis characterizing increased adhesion.
650 $aDogs
650 $aLymph nodes
650 $aMammary neoplasms (animal)
650 $aProteins
650 $aCão
650 $aProteína
650 $aTumor
653 $aInvasão
653 $aInvasion
653 $aLinfonodo
653 $aOncologia
653 $aOncology
700 1 $aMAGALHÃES, G. M.
700 1 $aCALAZANS, S. G.
700 1 $aCRIVELLENTI, L. Z.
700 1 $aLIMA, G. P.
700 1 $aMEDEIROS-RONCHI, A. A.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 37, n. 12, p. 1479-1482, dezembro 2017.
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Embrapa Unidades Centrais (AI-SEDE) |
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| 1. |  | MAGALHÃES, L. F.; MAGALHÃES, G. M.; CALAZANS, S. G.; CRIVELLENTI, L. Z.; LIMA, G. P.; MEDEIROS-RONCHI, A. A. Imunomarcação da transição epitélio-mesenquima na neoplasia mamária primária de cadelas e sua metástase em linfonodo. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 12, p. 1479-1482, dezembro 2017. Título em inglês: Epithelial to mesenchymal transition immunostaining in canine primary mammary tumor and lymph node.| Biblioteca(s): Embrapa Unidades Centrais. |
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