Data/hora: 03/06/2024 14:35:44

Biblioteca(s): | Embrapa Recursos Genéticos e Biotecnologia; Embrapa Unidades Centrais.
Data corrente: | 09/11/2018
Data da última atualização: | 23/06/2022
Autoria: | REBELATO, A. B.; CAETANO, A. R.
Afiliação: | Arnaldo Basso Rebelato, Universidade de Brasília - UnB; ALEXANDRE RODRIGUES CAETANO, Cenargen.
Título: | Runs of homozygosity for autozygosity estimation and genomic analysis in production animals.
Ano de publicação: | 2018
Fonte/Imprenta: | Pesquisa Agropecuária Brasileira, Brasília, DF, v. 53, n. 9, p. 975-984, Sept. 2018
Idioma: | Inglês
Conteúdo: | Runs of homozygosity (ROHs) are long stretches of homozygous genomic segments, identifiable by molecular markers, which can provide genomic information for accurate estimates to characterize populations, determine evolutionary history and demographic information, estimate levels of consanguinity, and identify selection signatures in production animals. This review paper aims to perform a survey of the works on the efficiency of ROHs for these purposes. Factors such as genetic drift, natural or artificial selection, founder effect, and effective population size directly influence the size and distribution of ROHs along the genome. Individually, genome estimates of consanguinity based on ROHs can be obtained using the F ROH index, which is generally considered more accurate than indexes based on other types of genomic or genealogical information. High frequencies of specific ROHs in a population can be used to identify selection signatures. The results of recent studies with ROHs in domestic animals have shown the efficiency of their use to characterize herds in a reliable and accessible way, using genomic information.
Palavras-Chave: | Autozygosity; F ROH; Selection signatures.
Thesaurus Nal: | Genotyping; Single nucleotide polymorphism.
Categoria do assunto: | --
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/185679/1/Runs-of-homozygosity-for-autozygosity.pdf
Registro original: | Embrapa Recursos Genéticos e Biotecnologia (CENARGEN)

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