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Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
17/09/2019 |
Data da última atualização: |
05/12/2023 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
BONATO, G. C.; CÔRTES, L. R.; ARRAIS, A. M.; FIGUEIRA, L. M.; OLIVEIRA, T. de A.; MACHADO, V. de O.; MAIA, A. L. R. e S.; SOUZA-FABJAN, J. M. G.; FONSECA, J. F. da. |
Afiliação: |
GISELE CALDAS BONATO, Universidade Federal de Viçosa (UFV) - Viçosa, MG, Brasil; LUANA RANGEL CÔRTES, Pós graduação - Universidade Federal Fluminense (UFF) - Niterói, RJ, Brasil; ALINE MATOS ARRAIS, Pós graduação - Instituto de Zootecnia; Universidade Federal Rural do Rio de Janeiro (UFRJ0 - Seropédica, RJ, Brasil; LUCAS MACHADO FIGUEIRA, Pós-graduação - Universidade Federal de Lavras (UFLA) - Lavras, MG; THAÍS DE ALMEIDA OLIVEIRA, Graduação - Universidade Presidente Antônio Carlos (UnipacJF) - Juiz de Fora, MG, Brasil; VITÓRIA DE OLIVEIRA MACHADO; ANA LÚCIA ROSA E SILVA MAIA, Pós graduação - Universidade Federal Fluminense (UFF) - Niterói, RJ, Brasil; JOANNA MARIA GONÇALVES SOUZA-FABJAN, Universidade Federal Fluminense (UFF) - Niterói, RJ, Brasil; JEFERSON FERREIRA DA FONSECA, CNPC. |
Título: |
Effects of two d-cloprostenol administrations given at different intervals on estrus and ovulation in cyclic dairy goats. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Revista Brasileira de Reprodução Animal, v. 43, n. 2, p. 538, abr./jun. 2019. |
Idioma: |
Inglês |
Notas: |
Edição dos resumos do XXIII Congresso Brasileiro de Reprodução Animal, Gramado, RS, Brasil, 15 a 17 de maio 2019. |
Conteúdo: |
Abstract: Goats are seasonal breeders depending on breed and latitude. Among the hormonal methods used in controlled reproduction programs, there are those that mimic the activity of the corpus luteum and those that inhibit it. Prostaglandin (PGF2?) fits the latter, with the advantage of having a better cost-benefit, since it is cheaper and more natural method, as it has fewer side effects than progestin devices. In addition, the literature is incipient regarding follicular and ovulatory data in goats subjected to PGF2? or its analogues. This study aimed to check in dairy goats the efficiency of estrus synchronization treatment using two doses of d-cloprostenol administered in different intervals, during the natural breeding season. The results quoted above suggest that the administration of dcloprostenol in cyclic dairy goats can efficiently synchronize estrus and ovulation and this fact encourages further studies using these protocols in association with Fixed Time Artificial Insemination in goats. [Efeitos de duas administrações de d-cloprostenol feitas em diferentes intervalos no estro e na ovulação em cabras leiteiras cíclicas]. |
Thesagro: |
Cabra Leiteira; Caprino; Ciclo Estral; Ovulação; Prostaglandina; Reprodução Animal; Sincronização do Cio. |
Thesaurus Nal: |
Animal reproduction; Dairy goats; Estrus synchronization; Ovulation; Prostaglandins. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/202059/1/CNPC-2019-Effects-of-two.pdf
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Marc: |
LEADER 02370nam a2200361 a 4500 001 2112241 005 2023-12-05 008 2019 bl uuuu u00u1 u #d 100 1 $aBONATO, G. C. 245 $aEffects of two d-cloprostenol administrations given at different intervals on estrus and ovulation in cyclic dairy goats.$h[electronic resource] 260 $aRevista Brasileira de Reprodução Animal, v. 43, n. 2, p. 538, abr./jun. 2019.$c2019 500 $aEdição dos resumos do XXIII Congresso Brasileiro de Reprodução Animal, Gramado, RS, Brasil, 15 a 17 de maio 2019. 520 $aAbstract: Goats are seasonal breeders depending on breed and latitude. Among the hormonal methods used in controlled reproduction programs, there are those that mimic the activity of the corpus luteum and those that inhibit it. Prostaglandin (PGF2?) fits the latter, with the advantage of having a better cost-benefit, since it is cheaper and more natural method, as it has fewer side effects than progestin devices. In addition, the literature is incipient regarding follicular and ovulatory data in goats subjected to PGF2? or its analogues. This study aimed to check in dairy goats the efficiency of estrus synchronization treatment using two doses of d-cloprostenol administered in different intervals, during the natural breeding season. The results quoted above suggest that the administration of dcloprostenol in cyclic dairy goats can efficiently synchronize estrus and ovulation and this fact encourages further studies using these protocols in association with Fixed Time Artificial Insemination in goats. [Efeitos de duas administrações de d-cloprostenol feitas em diferentes intervalos no estro e na ovulação em cabras leiteiras cíclicas]. 650 $aAnimal reproduction 650 $aDairy goats 650 $aEstrus synchronization 650 $aOvulation 650 $aProstaglandins 650 $aCabra Leiteira 650 $aCaprino 650 $aCiclo Estral 650 $aOvulação 650 $aProstaglandina 650 $aReprodução Animal 650 $aSincronização do Cio 700 1 $aCÔRTES, L. R. 700 1 $aARRAIS, A. M. 700 1 $aFIGUEIRA, L. M. 700 1 $aOLIVEIRA, T. de A. 700 1 $aMACHADO, V. de O. 700 1 $aMAIA, A. L. R. e S. 700 1 $aSOUZA-FABJAN, J. M. G. 700 1 $aFONSECA, J. F. da
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Embrapa Caprinos e Ovinos (CNPC) |
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Registro Completo
Biblioteca(s): |
Embrapa Alimentos e Territórios. |
Data corrente: |
17/11/2023 |
Data da última atualização: |
17/11/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
SANTOS, F. A.; VIANA, A. F. S. C.; NUNES, P. I. G.; PORTELA, B. Y. M.; ALVES, A. P. N. N.; VIANA, D. DE A.; CARVALHO, K. R.; PEREIRA, R. de C. A.; RIBEIRO, P. R. V.; ALVES FILHO, E. G.; BRITO, E. S. de; SILVEIRA, E. R.; CANUTO, K. M. |
Afiliação: |
FLÁVIA ALMEIDA SANTOS, Federal University of Ceará; ANA FLÁVIA SERAINE CUSTÓDIO VIANA, Federal University of Ceará; PAULO IURY GOMES NUNES, Federal University of Ceará; BENEDITO YAGO MACHADO PORTELA, Federal University of Ceará; ANA PAULA NEGREIROS NUNES ALVES, Federal University of Ceará; DANIEL DE ARAÚJO VIANA, Christhus University Center; KALINE RODRIGUES CARVALHO, Federal University of Ceara; RITA DE CASSIA ALVES PEREIRA, CNPAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; ELENILSON GODOY ALVES-FILHO; EDY SOUSA DE BRITO, CNAT; EDILBERTO ROCHA SILVEIRA, Federal University of Ceará; KIRLEY MARQUES CANUTO, CNPAT. |
Título: |
UPLC-QTOF-MS/MS-based metabolomic approach and gastroprotective effect of two chemotypes of Egletes viscosa (L.) less. against ethanol-induced gastric ulcer in mice. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Journal of Ethnopharmacology, 116348, june 2023. |
DOI: |
https://doi.org/10.1016/j.jep.2023.116348 |
Idioma: |
Inglês |
Conteúdo: |
Ethnopharmacological relevance: Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essential oil from the flower buds. Although there are previous studies of the gastroprotective effect of the isolated constituents of E. viscosa, its infusions have not been investigated yet. Aim of the study: The present study aimed to evaluate and compare the chemical composition and the gastroprotective effect of flower bud infusions of E. viscosa from chemotype A (EVCA) and chemotype B (EVCB). Materials and methods: Sixteen infusions were brewed with flower buds according to the traditional preparation mode and were analyzed through a UPLC-QTOF-MS/MS based metabolomic approach for determination of their metabolic fingerprints and quantification of bioactive compounds. Afterward, these data were analyzed by chemometric methods (OPLS-DA) for discrimination of the two chemotypes. Additionally, infusions of EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) were evaluated on gastric ulcers induced by absolute ethanol (96%, 0.2 mL, p.o.) in mice. To elucidate the gastroprotective mechanisms, the effect of EVCA and EVCB on gastric acid secretion and gastric wall mucus was determined and the role of TRPV1 channels, prostaglandins, nitric oxide and KATP channels were assessed. Moreover, the oxidative stress-related parameters and the histological aspects of the stomach tissue were analyzed. Results: The chemotypes can be discriminated from each other using UPLC-QTOF-MS/MS chemical fingerprints. Both chemotypes presented similar chemical compositions, consisting basically of caffeic acid derivatives, flavonoids and diterpenes. The quantification of bioactive compounds demonstrated that chemotype A possesses more ternatin, tanabalin and centipedic than chemotype B. EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) significantly decreased the severity of ethanol-induced gastric lesions, as shown by a reduction in histological alterations and leucocyte infiltration in gastric tissue. The gastroprotective mechanism of both infusions involves an antioxidant effect, maintenance of gastric mucus and reduction gastric secretion. Stimulation of endogenous prostaglandins and nitric oxide release, activation of TRPV1 channels, and KATP channels are also involved in the gastroprotection of the infusions. Conclusion: The gastroprotective effect of EVCA and EVCB was equivalent and mediated through antioxidant and antisecretory actions, including the activation of TRPV1 receptors, stimulation of endogenous prostaglandins and nitric oxide, and opening of KATP channels. The presence of caffeic acid derivatives, flavonoids and diterpenes in both infusions is involved in mediating this protective effect. Our findings support the traditional use of infusions of E. viscosa for gastric disorders regardless of the chemotype. MenosEthnopharmacological relevance: Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essential oil from the flower buds. Although there are previous studies of the gastroprotective effect of the isolated constituents of E. viscosa, its infusions have not been investigated yet. Aim of the study: The present study aimed to evaluate and compare the chemical composition and the gastroprotective effect of flower bud infusions of E. viscosa from chemotype A (EVCA) and chemotype B (EVCB). Materials and methods: Sixteen infusions were brewed with flower buds according to the traditional preparation mode and were analyzed through a UPLC-QTOF-MS/MS based metabolomic approach for determination of their metabolic fingerprints and quantification of bioactive compounds. Afterward, these data were analyzed by chemometric methods (OPLS-DA) for discrimination of the two chemotypes. Additionally, infusions of EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) were evaluated on gastric ulcers induced by absolute ethanol (96%, 0.2 mL, p.o.) in mice. To elucidate the gastroprotective mechanisms, the effect of EVCA and EVCB on gastric acid secretion and gastric wall mucus was determined and the role of TRPV1 channels, prostaglandins, nitric oxide ... Mostrar Tudo |
Palavras-Chave: |
Diterpenes; Egletes viscosa; Gastric ulcer. |
Thesaurus NAL: |
Flavonoids; Phenolic acids. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 04150naa a2200337 a 4500 001 2158523 005 2023-11-17 008 2023 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.jep.2023.116348$2DOI 100 1 $aSANTOS, F. A. 245 $aUPLC-QTOF-MS/MS-based metabolomic approach and gastroprotective effect of two chemotypes of Egletes viscosa (L.) less. against ethanol-induced gastric ulcer in mice.$h[electronic resource] 260 $c2023 520 $aEthnopharmacological relevance: Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essential oil from the flower buds. Although there are previous studies of the gastroprotective effect of the isolated constituents of E. viscosa, its infusions have not been investigated yet. Aim of the study: The present study aimed to evaluate and compare the chemical composition and the gastroprotective effect of flower bud infusions of E. viscosa from chemotype A (EVCA) and chemotype B (EVCB). Materials and methods: Sixteen infusions were brewed with flower buds according to the traditional preparation mode and were analyzed through a UPLC-QTOF-MS/MS based metabolomic approach for determination of their metabolic fingerprints and quantification of bioactive compounds. Afterward, these data were analyzed by chemometric methods (OPLS-DA) for discrimination of the two chemotypes. Additionally, infusions of EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) were evaluated on gastric ulcers induced by absolute ethanol (96%, 0.2 mL, p.o.) in mice. To elucidate the gastroprotective mechanisms, the effect of EVCA and EVCB on gastric acid secretion and gastric wall mucus was determined and the role of TRPV1 channels, prostaglandins, nitric oxide and KATP channels were assessed. Moreover, the oxidative stress-related parameters and the histological aspects of the stomach tissue were analyzed. Results: The chemotypes can be discriminated from each other using UPLC-QTOF-MS/MS chemical fingerprints. Both chemotypes presented similar chemical compositions, consisting basically of caffeic acid derivatives, flavonoids and diterpenes. The quantification of bioactive compounds demonstrated that chemotype A possesses more ternatin, tanabalin and centipedic than chemotype B. EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) significantly decreased the severity of ethanol-induced gastric lesions, as shown by a reduction in histological alterations and leucocyte infiltration in gastric tissue. The gastroprotective mechanism of both infusions involves an antioxidant effect, maintenance of gastric mucus and reduction gastric secretion. Stimulation of endogenous prostaglandins and nitric oxide release, activation of TRPV1 channels, and KATP channels are also involved in the gastroprotection of the infusions. Conclusion: The gastroprotective effect of EVCA and EVCB was equivalent and mediated through antioxidant and antisecretory actions, including the activation of TRPV1 receptors, stimulation of endogenous prostaglandins and nitric oxide, and opening of KATP channels. The presence of caffeic acid derivatives, flavonoids and diterpenes in both infusions is involved in mediating this protective effect. Our findings support the traditional use of infusions of E. viscosa for gastric disorders regardless of the chemotype. 650 $aFlavonoids 650 $aPhenolic acids 653 $aDiterpenes 653 $aEgletes viscosa 653 $aGastric ulcer 700 1 $aVIANA, A. F. S. C. 700 1 $aNUNES, P. I. G. 700 1 $aPORTELA, B. Y. M. 700 1 $aALVES, A. P. N. N. 700 1 $aVIANA, D. DE A. 700 1 $aCARVALHO, K. R. 700 1 $aPEREIRA, R. de C. A. 700 1 $aRIBEIRO, P. R. V. 700 1 $aALVES FILHO, E. G. 700 1 $aBRITO, E. S. de 700 1 $aSILVEIRA, E. R. 700 1 $aCANUTO, K. M. 773 $tJournal of Ethnopharmacology, 116348, june 2023.
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