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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
28/08/2018 |
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Data da última atualização: |
21/05/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OKINO, C. H.; MORES, M. A. Z.; TREVISOL, I. M.; COLDEBELLA, A.; MONTASSIER, H. J.; BRENTANO, L. |
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Afiliação: |
CINTIA HIROMI OKINO, CPPSE; MARCOS ANTONIO ZANELLA MORES, CNPSA; IARA MARIA TREVISOL, CNPSA; ARLEI COLDEBELLA, CNPSA; Hélio José Montassier, UNESP; LIANA BRENTANO, CNPSA. |
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Título: |
Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Plos One, v. 12, p. 1-17, fev. 2017. |
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Volume: |
12 |
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Páginas: |
1-17 |
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Idioma: |
Inglês |
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Conteúdo: |
Avian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken. MenosAvian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability ... Mostrar Tudo |
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Thesagro: |
Bronquite; Frango. |
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Thesaurus Nal: |
Bronchitis; Chickens; Infectious bronchitis; Infectious bronchitis virus. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/182004/1/Okino-PONE-2017.pdf
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Marc: |
LEADER 02335naa a2200277 a 4500
001 2094609
005 2019-05-21
008 2017 bl uuuu u00u1 u #d
100 1 $aOKINO, C. H.
245 $aEarly immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles.$h[electronic resource]
260 $c2017
300 $a1-17 12
490 $v12
520 $aAvian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken.
650 $aBronchitis
650 $aChickens
650 $aInfectious bronchitis
650 $aInfectious bronchitis virus
650 $aBronquite
650 $aFrango
700 1 $aMORES, M. A. Z.
700 1 $aTREVISOL, I. M.
700 1 $aCOLDEBELLA, A.
700 1 $aMONTASSIER, H. J.
700 1 $aBRENTANO, L.
773 $tPlos One$gv. 12, p. 1-17, fev. 2017.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Registro |
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Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
31/03/2011 |
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Data da última atualização: |
03/07/2013 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
PESSOA, J. R. C.; BREDER, R. L. B.; CRUVINEL, P. E.; LASSO, P. R. O. |
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Afiliação: |
PAULO ESTEVAO CRUVINEL, CNPDIA; PAULO RENATO ORLANDI LASSO, CNPDIA. |
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Título: |
Determination of concrete features by images obtained from X-ray microtomography. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
In: EUROPEAN CONFERENCE ON X-RAY SPECTROMETRY, EXRS, 2010, Figueira da Foz. Book of Abstracts... Coimbra: University of Coimbra, 2010. p. 191. |
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Idioma: |
Inglês |
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Palavras-Chave: |
Evento. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/85419/1/Proci-10.00309.pdf
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Marc: |
LEADER 00538nam a2200145 a 4500
001 1884319
005 2013-07-03
008 2010 bl uuuu u00u1 u #d
100 1 $aPESSOA, J. R. C.
245 $aDetermination of concrete features by images obtained from X-ray microtomography.
260 $aIn: EUROPEAN CONFERENCE ON X-RAY SPECTROMETRY, EXRS, 2010, Figueira da Foz. Book of Abstracts... Coimbra: University of Coimbra, 2010. p. 191.$c2010
653 $aEvento
700 1 $aBREDER, R. L. B.
700 1 $aCRUVINEL, P. E.
700 1 $aLASSO, P. R. O.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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