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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
09/10/2018 |
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Data da última atualização: |
13/12/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
RODRIGUES, R.; GUERRA, G.; SOARES, J.; SANTOS, K. M. O. dos; ROLIM F.; ASSIS, P.; ARAUJO, D.; ARAÚJO JÚNIOR, R. F. de; GARCIA, V. B.; ARAÚJO, A. A. de; QUEIROGA, R. |
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Afiliação: |
Raphaela Rodrigues, UFP; Gerlane Guerra, UFRJ; Juliana Soares, UFCG; KARINA MARIA OLBRICH DOS SANTOS, CTAA; Fernanda Rolim, UFP; Paloma Assis, UFP; Daline Araújo, UFRN; Raimundo F. de Araújo Júnior, UFRJ; Vinícius B. Garcia, UFRN; Aurigena A. de Araújo, UFRN; Rita Queirogaa, UFP. |
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Título: |
Lactobacillus rhamnosus EM1107 in goat milk matrix modulates intestinal inflammation involving NF-kB p65 and SOCs-1 in an acid-induced colitis model. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Journal of Functional Foods, v. 50, p. 78-92, 2018. |
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Idioma: |
Português |
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Conteúdo: |
Inflammatory Bowel Diseases (IBD) is characterized by a deregulated immune response. Probiotics are able to modulate the intestinal microbiota and regulating inflammatory responses. This study evaluated the effect of pretreatment of Lactobacillus rhamnosus EM1107, isolated (EM1107) or added to goat cheese (LRC), on acetic acid-induced colitis in rats. EM1107 or LRC had a protective effect on intestinal inflammation, with the improvement of disease activity index and macroscopic damage caused by inflammation. It also reduced myeloperoxidase, TNF-?, IL-1? colonic levels and improved oxidative stress. The histological evaluation confirmed the beneficial effect in colonic tissue preservation. Intestinal immunohistochemical analysis revealed down-regulation of IL-17, NF-?B p65, MMP-2, MMP-9, and iNOS expression, up-regulation of SOCs-1, ZO-1 and MUC-2, which are important intestinal mucosal barrier proteins. These results suggest that Lactobacillus rhamnosus EM1107 alone or added to goat cheese exerts a preventive effect against acetic acid-induced damage and may be an alternative to human IBD. |
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Thesaurus Nal: |
Probiotics. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01884naa a2200253 a 4500
001 2097063
005 2018-12-13
008 2018 bl uuuu u00u1 u #d
100 1 $aRODRIGUES, R.
245 $aLactobacillus rhamnosus EM1107 in goat milk matrix modulates intestinal inflammation involving NF-kB p65 and SOCs-1 in an acid-induced colitis model.$h[electronic resource]
260 $c2018
520 $aInflammatory Bowel Diseases (IBD) is characterized by a deregulated immune response. Probiotics are able to modulate the intestinal microbiota and regulating inflammatory responses. This study evaluated the effect of pretreatment of Lactobacillus rhamnosus EM1107, isolated (EM1107) or added to goat cheese (LRC), on acetic acid-induced colitis in rats. EM1107 or LRC had a protective effect on intestinal inflammation, with the improvement of disease activity index and macroscopic damage caused by inflammation. It also reduced myeloperoxidase, TNF-?, IL-1? colonic levels and improved oxidative stress. The histological evaluation confirmed the beneficial effect in colonic tissue preservation. Intestinal immunohistochemical analysis revealed down-regulation of IL-17, NF-?B p65, MMP-2, MMP-9, and iNOS expression, up-regulation of SOCs-1, ZO-1 and MUC-2, which are important intestinal mucosal barrier proteins. These results suggest that Lactobacillus rhamnosus EM1107 alone or added to goat cheese exerts a preventive effect against acetic acid-induced damage and may be an alternative to human IBD.
650 $aProbiotics
700 1 $aGUERRA, G.
700 1 $aSOARES, J.
700 1 $aSANTOS, K. M. O. dos
700 1 $aROLIM F.
700 1 $aASSIS, P.
700 1 $aARAUJO, D.
700 1 $aARAÚJO JÚNIOR, R. F. de
700 1 $aGARCIA, V. B.
700 1 $aARAÚJO, A. A. de
700 1 $aQUEIROGA, R.
773 $tJournal of Functional Foods$gv. 50, p. 78-92, 2018.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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