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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
06/07/2017 |
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Data da última atualização: |
06/07/2017 |
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Autoria: |
SWIATLO, N.; O'CONNOR, D. L.; ANDREWS, J.; PICCIANO, M. F. |
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Título: |
Relative folate bioavailability from diets containing human, bovine and goat milk. |
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Ano de publicação: |
1990 |
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Fonte/Imprenta: |
The Journal of Nutrition, v. 120, n. 2, p. 172-177, Feb. 1990. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The present study was designed to determine the relative folate bioavailability from diets containing human, bovine or goat milk and the relative sensitivity of various response criteria used in assessing folate bioavailability. Following a 12-wk depletion period, 16 groups of male rats (n = 5/group) were fed experimental diets with or without 20% milk solids and graded levels of folic acid for 4 wk. Total folates were measured in plasma, erythrocytes, liver and kidney. Bioavailability of dietary folate was determined using slope-ratio statistics. Plasma response was found to be the most sensitive indicator of folate bioavailability based on steepness of slope, goodness of fit (r = 0.96, P less than 0.01) and linearity of response over the entire range of folate intakes. Kidney folate concentration also showed a significant linear relationship to total folate intake (r = 0.69, P less than 0.01). Liver and erythrocyte folate concentrations were not correlated with folate intake (r = 0.33 and r = 0.22, respectively). Using plasma folate as the response criterion, dietary incorporation of human milk significantly enhanced folate bioavailability by 75% (P less than 0.01). With kidney as the response tissue, folate bioavailability from diets containing human and bovine milk was significantly enhanced over milk-free diets. These results show that incorporation of human or bovine milk into diets enhances folate bioavailability and that plasma and kidney folate concentrations are sensitive and specific indicators of folate bioavailability. MenosAbstract: The present study was designed to determine the relative folate bioavailability from diets containing human, bovine or goat milk and the relative sensitivity of various response criteria used in assessing folate bioavailability. Following a 12-wk depletion period, 16 groups of male rats (n = 5/group) were fed experimental diets with or without 20% milk solids and graded levels of folic acid for 4 wk. Total folates were measured in plasma, erythrocytes, liver and kidney. Bioavailability of dietary folate was determined using slope-ratio statistics. Plasma response was found to be the most sensitive indicator of folate bioavailability based on steepness of slope, goodness of fit (r = 0.96, P less than 0.01) and linearity of response over the entire range of folate intakes. Kidney folate concentration also showed a significant linear relationship to total folate intake (r = 0.69, P less than 0.01). Liver and erythrocyte folate concentrations were not correlated with folate intake (r = 0.33 and r = 0.22, respectively). Using plasma folate as the response criterion, dietary incorporation of human milk significantly enhanced folate bioavailability by 75% (P less than 0.01). With kidney as the response tissue, folate bioavailability from diets containing human and bovine milk was significantly enhanced over milk-free diets. These results show that incorporation of human or bovine milk into diets enhances folate bioavailability and that plasma and kidney folate concentrati... Mostrar Tudo |
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Palavras-Chave: |
Cow milk; Human milk; Kidney. |
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Thesaurus Nal: |
Cattle; Erythrocytes; Folic Acid; Goat milk; Pharmacokinetics; Rats; Regression Analysis. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02295naa a2200277 a 4500
001 2072101
005 2017-07-06
008 1990 bl uuuu u00u1 u #d
100 1 $aSWIATLO, N.
245 $aRelative folate bioavailability from diets containing human, bovine and goat milk.
260 $c1990
520 $aAbstract: The present study was designed to determine the relative folate bioavailability from diets containing human, bovine or goat milk and the relative sensitivity of various response criteria used in assessing folate bioavailability. Following a 12-wk depletion period, 16 groups of male rats (n = 5/group) were fed experimental diets with or without 20% milk solids and graded levels of folic acid for 4 wk. Total folates were measured in plasma, erythrocytes, liver and kidney. Bioavailability of dietary folate was determined using slope-ratio statistics. Plasma response was found to be the most sensitive indicator of folate bioavailability based on steepness of slope, goodness of fit (r = 0.96, P less than 0.01) and linearity of response over the entire range of folate intakes. Kidney folate concentration also showed a significant linear relationship to total folate intake (r = 0.69, P less than 0.01). Liver and erythrocyte folate concentrations were not correlated with folate intake (r = 0.33 and r = 0.22, respectively). Using plasma folate as the response criterion, dietary incorporation of human milk significantly enhanced folate bioavailability by 75% (P less than 0.01). With kidney as the response tissue, folate bioavailability from diets containing human and bovine milk was significantly enhanced over milk-free diets. These results show that incorporation of human or bovine milk into diets enhances folate bioavailability and that plasma and kidney folate concentrations are sensitive and specific indicators of folate bioavailability.
650 $aCattle
650 $aErythrocytes
650 $aFolic Acid
650 $aGoat milk
650 $aPharmacokinetics
650 $aRats
650 $aRegression Analysis
653 $aCow milk
653 $aHuman milk
653 $aKidney
700 1 $aO'CONNOR, D. L.
700 1 $aANDREWS, J.
700 1 $aPICCIANO, M. F.
773 $tThe Journal of Nutrition$gv. 120, n. 2, p. 172-177, Feb. 1990.
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Embrapa Caprinos e Ovinos (CNPC) |
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