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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Solos. |
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Data corrente: |
23/02/2017 |
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Data da última atualização: |
10/11/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GONZALEZ, M. H.; SILVA, C. S. da; AMARAL, C. D. B.; BIANCHI, S. R.; OLIVEIRA, L. H. B. de; COELHO, J. S.; OLIVEIRA, A.; NOGUEIRA, A. R. de A. |
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Afiliação: |
Mario Henrique Gonzalez, UNESP; Caroline Santos da Silva, UFSCar; Clarice Dias Britto do Amaral, UFSCar; SILMARA ROSSANA BIANCHI, CNPS; Luciano Henrique Barca de Oliveira, UNESP; Jessica Silva Coelho, UNESP; Andrea Oliveira, UFPR; ANA RITA DE ARAUJO NOGUEIRA, CPPSE. |
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Título: |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017. |
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DOI: |
https://doi.org/10.5935/0103-5053.20160151 |
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Idioma: |
Inglês
Português |
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Conteúdo: |
Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr. |
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Palavras-Chave: |
Acyclovir; Elemental impurity; Impureza elementar; Pharmaceutical product; Produto farmacêutico. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/156641/1/0103-5053-jbchs-28-01-0098.pdf
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Marc: |
LEADER 02269naa a2200277 a 4500
001 2067515
005 2021-11-10
008 2017 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.5935/0103-5053.20160151$2DOI
100 1 $aGONZALEZ, M. H.
245 $aDetermination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS.$h[electronic resource]
260 $c2017
520 $aInorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr.
653 $aAcyclovir
653 $aElemental impurity
653 $aImpureza elementar
653 $aPharmaceutical product
653 $aProduto farmacêutico
700 1 $aSILVA, C. S. da
700 1 $aAMARAL, C. D. B.
700 1 $aBIANCHI, S. R.
700 1 $aOLIVEIRA, L. H. B. de
700 1 $aCOELHO, J. S.
700 1 $aOLIVEIRA, A.
700 1 $aNOGUEIRA, A. R. de A.
773 $tJournal of the Brazilian Chemical Society$gv. 28, n. 1, p. 98-105, 2017.
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Registro original: |
Embrapa Solos (CNPS) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio-Norte. Para informações adicionais entre em contato com cpamn.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Meio-Norte. |
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Data corrente: |
01/12/2022 |
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Data da última atualização: |
01/12/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PIRES, M. de F. M.; SOUZA, H. A. de; MEDERIOS, J. C.; ROSA, J. D.; MARTINS, R. V. de S.; SOBRAL, A. H. S.; CARVALHO, S. P.; VERA, G. de S.; VIEIRA, P. F. de M. J.; SAGRILO, E. |
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Afiliação: |
MARIA DE FÁTIMA MARQUES PIRES, FEDERAL UNIVERSITY OF PIAUÍ; HENRIQUE ANTUNES DE SOUZA, CPAMN; JOÃO CARLOS MEDERIOS, FEDERAL UNIVERSITY OF SOUTHERN BAHIA; JAQUELINE DALLA ROSA, FEDERAL UNIVERSITY OF SOUTHERN BAHIA; RAPHAEL VINICIUS DE SOUZA MARTINS, FEDERAL UNIVERSITY OF PIAUÍ; AMANDA HÉLLEN SALES SOBRAL, FEDERAL UNIVERSITY OF PIAUÍ; SUZANE PEREIRA CARVALHO, FEDERAL INSTITUTE OF EDUCATION, SCIENCE AND TECHNOLOGY OF PIAUÍ; GEANIA DE SOUSA VERA, FEDERAL UNIVERSITY OF PIAUÍ; PAULO FERNANDO DE MELO JORGE VIEIRA, CPAMN; EDVALDO SAGRILO, CPAMN. |
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Título: |
Nutrient uptake by soybean plants in succession of cover crops in Northeast of Brazil. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Communications in Soil Science and Plant Analysis, 2022. Online. |
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DOI: |
https://doi.org/10.1080/00103624.2022.2137183 |
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Idioma: |
Inglês |
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Conteúdo: |
This study aimed to estimate the nutrient absorption rate in soybean plants cultivated in succession to cover crops and under soil management systems. |
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Palavras-Chave: |
Redistribuição; Sistema de manejo do solo. |
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Thesagro: |
Glycine Max; Nutriente; Plantio Direto. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 01071naa a2200301 a 4500
001 2149092
005 2022-12-01
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1080/00103624.2022.2137183$2DOI
100 1 $aPIRES, M. de F. M.
245 $aNutrient uptake by soybean plants in succession of cover crops in Northeast of Brazil.$h[electronic resource]
260 $c2022
520 $aThis study aimed to estimate the nutrient absorption rate in soybean plants cultivated in succession to cover crops and under soil management systems.
650 $aGlycine Max
650 $aNutriente
650 $aPlantio Direto
653 $aRedistribuição
653 $aSistema de manejo do solo
700 1 $aSOUZA, H. A. de
700 1 $aMEDERIOS, J. C.
700 1 $aROSA, J. D.
700 1 $aMARTINS, R. V. de S.
700 1 $aSOBRAL, A. H. S.
700 1 $aCARVALHO, S. P.
700 1 $aVERA, G. de S.
700 1 $aVIEIRA, P. F. de M. J.
700 1 $aSAGRILO, E.
773 $tCommunications in Soil Science and Plant Analysis, 2022. Online.
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Embrapa Meio-Norte (CPAMN) |
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