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Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
08/09/2017 |
Data da última atualização: |
20/05/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
DUARTE JUNIOR, A. P.; TAVARES, E. J. M.; ALVES, T. V. G.; MOURA, M. R. de; COSTA, C. E. F. da; SILVA JÚNIOR, J. O. C.; COSTA, R. M. R. |
Afiliação: |
Anivaldo Pereira Duarte Junior, UFPA; ERALDO JOSE MADUREIRA TAVARES, CPATU; Taís Vanessa Gabbay Alves, UFPA; Márcia Regina de Moura, UNESP; Carlos Emmerson Ferreira da Costa, UFPA; José Otávio Carréra Silva Júnior, UFPA; Roseane Maria Ribeiro Costa, UFPA. |
Título: |
Chitosan nanoparticles as a modified diclofenac drug release system. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of Nanoparticle Research, v. 19, n. 8, article 274, 2017. |
DOI: |
10.1007/s11051-017-3968-6 |
Idioma: |
Inglês |
Conteúdo: |
This study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport. MenosThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and o... Mostrar Tudo |
Palavras-Chave: |
Biopolímero; Nanopartícula; Nanotecnologia; Quitosana. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 02347naa a2200253 a 4500 001 2075279 005 2022-05-20 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1007/s11051-017-3968-6$2DOI 100 1 $aDUARTE JUNIOR, A. P. 245 $aChitosan nanoparticles as a modified diclofenac drug release system.$h[electronic resource] 260 $c2017 520 $aThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport. 653 $aBiopolímero 653 $aNanopartícula 653 $aNanotecnologia 653 $aQuitosana 700 1 $aTAVARES, E. J. M. 700 1 $aALVES, T. V. G. 700 1 $aMOURA, M. R. de 700 1 $aCOSTA, C. E. F. da 700 1 $aSILVA JÚNIOR, J. O. C. 700 1 $aCOSTA, R. M. R. 773 $tJournal of Nanoparticle Research$gv. 19, n. 8, article 274, 2017.
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Embrapa Amazônia Oriental (CPATU) |
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Registros recuperados : 5 | |
1. | | ALVES, T. V. G.; MATONDO, R. M.; DINIZ, J. A. P.; TAVARES, E. J. M.; AOUADA, F. A.; RIBEIRO-COSTA, R. M. Physicochemical characterization of PAAM-CO-MC hydrogels as controlled release systems. In: INTERNATIONAL CONGRESS OF PHARMACEUTICAL SCIENCES, 8., 2011, Ribeirão Preto. New trends in pharmaceutical sciences: proceedings. Ribeirão Preto: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, 2011.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Amazônia Oriental. |
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2. | | DUARTE JUNIOR, A. P.; TAVARES, E. J. M.; ALVES, T. V. G.; MOURA, M. R. de; COSTA, C. E. F. da; SILVA JÚNIOR, J. O. C.; COSTA, R. M. R. Chitosan nanoparticles as a modified diclofenac drug release system. Journal of Nanoparticle Research, v. 19, n. 8, article 274, 2017.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Amazônia Oriental. |
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3. | | DUARTE JUNIOR, A. P.; ALVES, T. V. G.; TAVARES, E. J. M.; MOURA, M. R. de; OLIVEIRA, M. E. C.; COSTA, C. E. F. da; COSTA, R. M. R.; SILVA JUNIOR, J. O. C. Caracterização térmica de nanopartículas de quitosana. In: CONGRESSO BRASILEIRO DE ANÁLISE TÉRMICA E CALORIMETRIA, 7., 2010, São Pedro. [Anais]. [São Paulo]: ABRATEC, 2010.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Amazônia Oriental. |
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4. | | ALVES, T. V. G.; DUARTE JUNIOR, A. P.; TAVARES, E. J. M.; AOUADA, F. A.; OLIVEIRA, M. E. C.; COSTA, C. E. F. da; SILVA JUNIOR, J. O. C.; COSTA, R. M. R. Estudo termoanalítico de hidrogel de PAAM-C-MC e dos manômeros AAm E MC. In: CONGRESSO BRASILEIRO DE ANÁLISE TÉRMICA E CALORIMETRIA, 7., 2010, São Pedro. [Anais]. [São Paulo]: ABRATEC, 2010.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Amazônia Oriental. |
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5. | | ALVES, T. V. G.; TAVARES, E. J. M.; AOUADA, F. A.; NEGRÃO, C. A. B.; OLIVEIRA, M. E. C.; DUARTE JÚNIOR, A. P.; COSTA, C. E. F. da; SILVA JÚNIOR, J. O. C.; COSTA, R. M. R. Thermal analysis characterization of PAAm-co-MC hydrogels. Journal of Thermal Analysis and Calorimetry, v. 106, n. 3, p. 717-724, 2011.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Amazônia Oriental. |
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Registros recuperados : 5 | |
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Nenhum registro encontrado para a expressão de busca informada. |
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