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Registro Completo |
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Biblioteca(s): |
Embrapa Semiárido. |
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Data corrente: |
16/11/2018 |
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Data da última atualização: |
16/11/2018 |
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Autoria: |
ALMEIDA, M. B. de. |
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Título: |
Estimativa do estoque de capital no Nordeste e Sudeste do Brasil - 1970. |
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Ano de publicação: |
1981 |
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Fonte/Imprenta: |
Revista Econômica do Nordeste, Fortaleza, v. 12, n. 2, p. 277-303, abr./jun. 1981. |
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Idioma: |
Português |
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Conteúdo: |
Procura-se aqui estimar o estoque de capital, em 1970, para o Nordeste e o Sudeste do Brasil. |
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Palavras-Chave: |
Nordeste; Sudeste. |
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Thesagro: |
Indústria. |
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Thesaurus Nal: |
Industry. |
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Categoria do assunto: |
E Economia e Indústria Agrícola |
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Marc: |
LEADER 00577naa a2200169 a 4500
001 2099488
005 2018-11-16
008 1981 bl uuuu u00u1 u #d
100 1 $aALMEIDA, M. B. de
245 $aEstimativa do estoque de capital no Nordeste e Sudeste do Brasil - 1970.
260 $c1981
520 $aProcura-se aqui estimar o estoque de capital, em 1970, para o Nordeste e o Sudeste do Brasil.
650 $aIndustry
650 $aIndústria
653 $aNordeste
653 $aSudeste
773 $tRevista Econômica do Nordeste, Fortaleza$gv. 12, n. 2, p. 277-303, abr./jun. 1981.
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Registro original: |
Embrapa Semiárido (CPATSA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Milho e Sorgo. Para informações adicionais entre em contato com cnpms.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Milho e Sorgo. |
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Data corrente: |
01/12/2016 |
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Data da última atualização: |
01/12/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 1 |
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Autoria: |
GIUSEPPE, P. O. de; SANTOS, M. L. dos; SOUSA, S. M. de; KOCH, K. E.; YUNES, J. A.; APARICIO, R.; MURAKAMI, M. T. |
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Afiliação: |
Priscila Oliveira de Giuseppe, Centro Nacional de Pesquisa em Energia e Materiais - CNPEM; Marcelo Leite dos Santos, Universidade de Campinas; SYLVIA MORAIS DE SOUSA TINOCO, CNPMS; Karen E. Koch, Universidade da Florida; José Andrés Yunes, Universidade de Campinas; Ricardo Aparicio, Universidade de Campinas; Mario Tyago Murakami, Centro Nacional de Pesquisa em Energia e Materiais - CNPEM. |
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Título: |
A comparative structural analysis reveals distinctive features of cofactor binding and substrate specificity in plant aldo-keto reductases. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Biochemical and Biophysical Research Communications, v. 474, p. 696-701, 2016. |
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DOI: |
10.1016/j.bbrc.2016.05.011 |
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Idioma: |
Inglês |
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Conteúdo: |
Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops. However, these AKR4Cs show little to no activity with previouslyenvisioned sugar substrates. We hypothesized a structural basis for the distinctive cofactor binding and substrate specificity of these plant enzymes. To test this, we solved the crystal structure of a novel AKR4C subfamily member, the AKR4C7 from maize, in the apo form and in complex with NADPþ. The binary complex revealed an intermediate state of cofactor binding that preceded closure of Loop B, and also indicated that conformational changes upon substrate binding are required to induce a catalyticallyfavorable conformation of the active-site pocket. Comparative structural analyses of homologues (AKR1B1, AKR4C8 and AKR4C9) showed that evolutionary redesign of plant AKR4Cs weakened interactions that stabilize the closed conformation of Loop B. This in turn decreased cofactor affinity and altered configuration of the substrate-binding site. We propose that these structural modifications contribute to impairment of sugar reductase activity in favor of other substrates in the plant AKR4C subgroup, and that catalysis involves a three-step process relevant to other AKRs. |
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Thesagro: |
Enzima; Reductase. |
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Categoria do assunto: |
S Ciências Biológicas |
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Marc: |
LEADER 02042naa a2200229 a 4500
001 2057658
005 2016-12-01
008 2016 bl uuuu u00u1 u #d
024 7 $a10.1016/j.bbrc.2016.05.011$2DOI
100 1 $aGIUSEPPE, P. O. de
245 $aA comparative structural analysis reveals distinctive features of cofactor binding and substrate specificity in plant aldo-keto reductases.$h[electronic resource]
260 $c2016
520 $aPlant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops. However, these AKR4Cs show little to no activity with previouslyenvisioned sugar substrates. We hypothesized a structural basis for the distinctive cofactor binding and substrate specificity of these plant enzymes. To test this, we solved the crystal structure of a novel AKR4C subfamily member, the AKR4C7 from maize, in the apo form and in complex with NADPþ. The binary complex revealed an intermediate state of cofactor binding that preceded closure of Loop B, and also indicated that conformational changes upon substrate binding are required to induce a catalyticallyfavorable conformation of the active-site pocket. Comparative structural analyses of homologues (AKR1B1, AKR4C8 and AKR4C9) showed that evolutionary redesign of plant AKR4Cs weakened interactions that stabilize the closed conformation of Loop B. This in turn decreased cofactor affinity and altered configuration of the substrate-binding site. We propose that these structural modifications contribute to impairment of sugar reductase activity in favor of other substrates in the plant AKR4C subgroup, and that catalysis involves a three-step process relevant to other AKRs.
650 $aEnzima
650 $aReductase
700 1 $aSANTOS, M. L. dos
700 1 $aSOUSA, S. M. de
700 1 $aKOCH, K. E.
700 1 $aYUNES, J. A.
700 1 $aAPARICIO, R.
700 1 $aMURAKAMI, M. T.
773 $tBiochemical and Biophysical Research Communications$gv. 474, p. 696-701, 2016.
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