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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
22/06/2022 |
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Data da última atualização: |
10/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FIGUEIREDO, A.; ANHOLETO, L. A.; COLA, D. F.; FANTATTO, R. R.; SANTOS, I. B.; ALEMÁN GAINZA, Y.; SOUSA, G. A.; PICKETT, L. J.; FRACETO, L. F.; CHAGAS, A. C. de S. |
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Afiliação: |
AMANDA FIGUEIREDO, UNESP; LUÍS ADRIANO ANHOLETO, UNESP; DIEGO FARIA COLA, UNESP; RAFAELA REGINA FANTATTO, UNESP; ISABELLA BARBOSA SANTOS, UNESP; YOUSMEL ALEMÁN GAINZA, UNESP; GUSTAVO AVELAR SOUSA, UNESP; LAURA JANE PICKETT, Acadia University; LEONARDO FERNANDES FRACETO, UNESP; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Nanoformulations with synthetic and plant-derived compounds for cattle tick control. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 309, Sep. 2022, 109756. |
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Páginas: |
9 p. |
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DOI: |
https://doi.org/10.1016/j.vetpar.2022.109756 |
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Idioma: |
Inglês |
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Conteúdo: |
Nanocarriers of acaricidal compounds improve the bioavailability, absorption, and tissue distribution of active ingredients, releasing them in a slow, targeted way and protecting them against premature degradation. Thus, this study aimed to develop formulations from solid lipid nanoparticles (SLN), or nanostructured lipid carriers (NLC) associated with cypermethrin (cip) + chlorpyrifos (chlo) and vegetable compounds (citral, menthol, or limonene). Particles were then characterised, and their efficacy was verified on R. microplus in comparison to nanoformulations without the plant-based compounds. Six different formulations were developed and characterised by dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). Formulations 1 (SLN+cyp+chlo+citral), 2 (SLN+cyp+chlo+menthol), 3 (SLN+cyp+chlo+limonene), 4 (NLC+cyp+chlo+citral), 5 (NLC+cyp+chlo+menthol) and 6 (NLC+cyp+chlo+limonene) had mean diameters from 286 to 304 nm; polydispersion from 0.16 to 0.18; zeta potential from ?15.8 to −20 mV, concentration from 3.37 ± 0.24 × 1013 to 5.44 ± 0.18 × 1013 particles/mL and encapsulation efficiency (EE) > 98.01 % for all active ingredients. All formulations were evaluated for their acaricidal potential by the larval packet test (LPT) and compared with nanoformulations without the plant-based compounds. Formulations were also compared with positive (Colosso® at 512 µg/mL) and negative controls (distilled water and nanoparticles without active ingredients). The SLN (1, 2 and 3) and NLC (4, 5 and 6) formulations, at 7 µg/mL, resulted in 90.4 % , 75.9 % , 93.8 % , 100 % , 95.1 % and 72.7 % mortality. The data demonstrated that the addition of citral, menthol or limonene in the formulations improved their acaricide action against tick larvae. Except for formulation 4, for which it was not possible to determine lethal concentrations (LC). Formulations, 1, 2, 3, 5 and 6 reached LC50 and LC90 values of 3.3 and 7.2, 5.4 and 9.2, 4.0 and 8.1, 2.3 and 5.4 as well as 5.5 and 9.4 µg/mL, respectively. It was possible to encapsulate the active ingredients and characterise the lipid carrier systems. SLN and NLC protected the active ingredients against degradation in solution and increased the overall stability. A stabile solution is necessary for synthesizing commercial acaricidal products. It is hoped that these findings may contribute to new studies focused on the use of nanocarriers in tick formulations. By reducing the amount or concentration of active ingredients within commercial products, the risk of residues presents in food of animal origin or remaining in the environment is reduced. Nanocarriers help prevent these challenges, while still maintaining effective parasitic control. Utilizing a combination of natural and synthetic products can be part of integrated management solutions and can help overcome widespread acaricide resistance in populations of cattle ticks. MenosNanocarriers of acaricidal compounds improve the bioavailability, absorption, and tissue distribution of active ingredients, releasing them in a slow, targeted way and protecting them against premature degradation. Thus, this study aimed to develop formulations from solid lipid nanoparticles (SLN), or nanostructured lipid carriers (NLC) associated with cypermethrin (cip) + chlorpyrifos (chlo) and vegetable compounds (citral, menthol, or limonene). Particles were then characterised, and their efficacy was verified on R. microplus in comparison to nanoformulations without the plant-based compounds. Six different formulations were developed and characterised by dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). Formulations 1 (SLN+cyp+chlo+citral), 2 (SLN+cyp+chlo+menthol), 3 (SLN+cyp+chlo+limonene), 4 (NLC+cyp+chlo+citral), 5 (NLC+cyp+chlo+menthol) and 6 (NLC+cyp+chlo+limonene) had mean diameters from 286 to 304 nm; polydispersion from 0.16 to 0.18; zeta potential from ?15.8 to −20 mV, concentration from 3.37 ± 0.24 × 1013 to 5.44 ± 0.18 × 1013 particles/mL and encapsulation efficiency (EE) > 98.01 % for all active ingredients. All formulations were evaluated for their acaricidal potential by the larval packet test (LPT) and compared with nanoformulations without the plant-based compounds. Formulations were also compared with positive (Colosso® at 512 µg/mL) and negative controls (distilled water and nanoparticles without active ingredients). The SL... Mostrar Tudo |
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Palavras-Chave: |
Cattle tick; Nanostructured lipid carriers; Plant isolates; Solid lipid nanoparticles. |
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Thesaurus Nal: |
Chlorpyrifos; Cypermethrin. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 03893naa a2200325 a 4500
001 2144233
005 2023-03-10
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.vetpar.2022.109756$2DOI
100 1 $aFIGUEIREDO, A.
245 $aNanoformulations with synthetic and plant-derived compounds for cattle tick control.$h[electronic resource]
260 $c2022
300 $a9 p.
520 $aNanocarriers of acaricidal compounds improve the bioavailability, absorption, and tissue distribution of active ingredients, releasing them in a slow, targeted way and protecting them against premature degradation. Thus, this study aimed to develop formulations from solid lipid nanoparticles (SLN), or nanostructured lipid carriers (NLC) associated with cypermethrin (cip) + chlorpyrifos (chlo) and vegetable compounds (citral, menthol, or limonene). Particles were then characterised, and their efficacy was verified on R. microplus in comparison to nanoformulations without the plant-based compounds. Six different formulations were developed and characterised by dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). Formulations 1 (SLN+cyp+chlo+citral), 2 (SLN+cyp+chlo+menthol), 3 (SLN+cyp+chlo+limonene), 4 (NLC+cyp+chlo+citral), 5 (NLC+cyp+chlo+menthol) and 6 (NLC+cyp+chlo+limonene) had mean diameters from 286 to 304 nm; polydispersion from 0.16 to 0.18; zeta potential from ?15.8 to −20 mV, concentration from 3.37 ± 0.24 × 1013 to 5.44 ± 0.18 × 1013 particles/mL and encapsulation efficiency (EE) > 98.01 % for all active ingredients. All formulations were evaluated for their acaricidal potential by the larval packet test (LPT) and compared with nanoformulations without the plant-based compounds. Formulations were also compared with positive (Colosso® at 512 µg/mL) and negative controls (distilled water and nanoparticles without active ingredients). The SLN (1, 2 and 3) and NLC (4, 5 and 6) formulations, at 7 µg/mL, resulted in 90.4 % , 75.9 % , 93.8 % , 100 % , 95.1 % and 72.7 % mortality. The data demonstrated that the addition of citral, menthol or limonene in the formulations improved their acaricide action against tick larvae. Except for formulation 4, for which it was not possible to determine lethal concentrations (LC). Formulations, 1, 2, 3, 5 and 6 reached LC50 and LC90 values of 3.3 and 7.2, 5.4 and 9.2, 4.0 and 8.1, 2.3 and 5.4 as well as 5.5 and 9.4 µg/mL, respectively. It was possible to encapsulate the active ingredients and characterise the lipid carrier systems. SLN and NLC protected the active ingredients against degradation in solution and increased the overall stability. A stabile solution is necessary for synthesizing commercial acaricidal products. It is hoped that these findings may contribute to new studies focused on the use of nanocarriers in tick formulations. By reducing the amount or concentration of active ingredients within commercial products, the risk of residues presents in food of animal origin or remaining in the environment is reduced. Nanocarriers help prevent these challenges, while still maintaining effective parasitic control. Utilizing a combination of natural and synthetic products can be part of integrated management solutions and can help overcome widespread acaricide resistance in populations of cattle ticks.
650 $aChlorpyrifos
650 $aCypermethrin
653 $aCattle tick
653 $aNanostructured lipid carriers
653 $aPlant isolates
653 $aSolid lipid nanoparticles
700 1 $aANHOLETO, L. A.
700 1 $aCOLA, D. F.
700 1 $aFANTATTO, R. R.
700 1 $aSANTOS, I. B.
700 1 $aALEMÁN GAINZA, Y.
700 1 $aSOUSA, G. A.
700 1 $aPICKETT, L. J.
700 1 $aFRACETO, L. F.
700 1 $aCHAGAS, A. C. de S.
773 $tVeterinary Parasitology$gv. 309, Sep. 2022, 109756.
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Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
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Biblioteca(s): |
Embrapa Agropecuária Oeste. |
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Data corrente: |
03/09/2010 |
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Data da última atualização: |
08/04/2011 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
MELO, C. L. P. de; TEIXEIRA, M. do R. de O.; ARIAS, C. A. A.; PIPOLO, A. E.; CARNEIRO, G. E. S.; KASTER, M.; OLIVEIRA, M. F.; DIAS, W. P.; SOARES, R. M.; MOREIRA, J. U. V.; TOLEDO, J. F. F.; ALMEIDA, A. M. R. |
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Afiliação: |
CARLOS LASARO PEREIRA DE MELO, CPAO; MARIA DO ROSARIO DE O TEIXEIRA, CPAO. |
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Título: |
BRS 318 RR: cultivar de soja transgência indica para cultivo em Mato Grosso do Sul. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
In: REUNIÃO DE PESQUISA DE SOJA DA REGIÃO CENTRAL DO BRASIL, 31., 2010, Brasília, DF. Resumos... Londrina: Embrapa Soja, 2010. p. 271-273. Editores técnicos: Adilson de Oliveira Junior, Odilon Ferreira Saraiva, Regina Maria Villas Bôas de Campo Leite, César de Castro, Jussara Flores de Oliveira Arbues, Wellington Cavalcanti. |
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Idioma: |
Português |
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Palavras-Chave: |
Cultivar de soja. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01016naa a2200253 a 4500
001 1861826
005 2011-04-08
008 2010 bl uuuu u00u1 u #d
100 1 $aMELO, C. L. P. de
245 $aBRS 318 RR$bcultivar de soja transgência indica para cultivo em Mato Grosso do Sul.
260 $c2010
653 $aCultivar de soja
700 1 $aTEIXEIRA, M. do R. de O.
700 1 $aARIAS, C. A. A.
700 1 $aPIPOLO, A. E.
700 1 $aCARNEIRO, G. E. S.
700 1 $aKASTER, M.
700 1 $aOLIVEIRA, M. F.
700 1 $aDIAS, W. P.
700 1 $aSOARES, R. M.
700 1 $aMOREIRA, J. U. V.
700 1 $aTOLEDO, J. F. F.
700 1 $aALMEIDA, A. M. R.
773 $tIn: REUNIÃO DE PESQUISA DE SOJA DA REGIÃO CENTRAL DO BRASIL, 31., 2010, Brasília, DF. Resumos... Londrina: Embrapa Soja, 2010. p. 271-273. Editores técnicos: Adilson de Oliveira Junior, Odilon Ferreira Saraiva, Regina Maria Villas Bôas de Campo Leite, César de Castro, Jussara Flores de Oliveira Arbues, Wellington Cavalcanti.
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