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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
08/09/2020 |
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Data da última atualização: |
10/09/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
AFONSO, J.; FORTES, M. R. S.; REVERTER, A.; DINIZ, W. J. da S.; CESAR, A. S. M.; LIMA, A. O. de; PETRINI, J.; SOUZA, M. de S.; COUTINHO, L. L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; REGITANO, L. C. de A. |
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Afiliação: |
JULIANA AFONSO, UFSCar; MARINA RUFINO SALINAS FORTES, The University of Queensland; ANTONIO REVERTER, Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Brisbane; WELLISON JARLES DA SILVA DINIZ, UFSCar; ALINE SILVA MELLO CESAR, Esalq/USP; ANDRESSA OLIVEIRA DE LIMA, UFSCar; JULIANA PETRINI, UNIFAL; MARCELA M. DE SOUZA, Iowa State University; LUIZ LEHMANN COUTINHO, Esalq/USP; GERSON BARRETO MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; CAIO FERNANDO GROMBONI, Bahia Federal Institute of Education, Science and Technology, Ilhéus; ANA RITA ARAÚJO NOGUEIRA; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Genetic regulators of mineral amount in Nelore cattle muscle predicted by a new co-expression and regulatory impact factor approach. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Scientific Reports, v. 10, n. 1, p. 1-16, 2020 |
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DOI: |
https://doi.org/10.1038/s41598-020-65454-7 |
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Idioma: |
Inglês |
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Notas: |
Article: 8436. |
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Conteúdo: |
Mineral contents in bovine muscle can affect meat quality, growth, health, and reproductive traits. To better understand the genetic basis of this phenotype in Nelore (Bos indicus) cattle, we analysed genome-wide mRNA and miRNA expression data from 114 muscle samples. The analysis implemented a new application for two complementary algorithms: the partial correlation and information theory (PCIT) and the regulatory impact factor (RIF), in which we included the estimated genomic breeding values (GEBVs) for the phenotypes additionally to the expression levels, originally proposed for these methods. We used PCIT to determine putative regulatory relationships based on significant associations between gene expression and GEBVs for each mineral amount. Then, RIF was adopted to determine the regulatory impact of genes and miRNAs expression over the GEBVs for the mineral amounts. We also investigated over-represented pathways, as well as pieces of evidences from previous studies carried in the same population and in the literature, to determine regulatory genes for the mineral amounts. For example, NOX1 expression level was positively correlated to Zinc and has been described as Zinc-regulated in humans. Based on our approach, we were able to identify genes, miRNAs and pathways not yet described as underlying mineral amount. The results support the hypothesis that extracellular matrix interactions are the core regulator of mineral amount in muscle cells. Putative regulators described here add information to this hypothesis, expanding the knowledge on molecular relationships between gene expression and minerals. MenosMineral contents in bovine muscle can affect meat quality, growth, health, and reproductive traits. To better understand the genetic basis of this phenotype in Nelore (Bos indicus) cattle, we analysed genome-wide mRNA and miRNA expression data from 114 muscle samples. The analysis implemented a new application for two complementary algorithms: the partial correlation and information theory (PCIT) and the regulatory impact factor (RIF), in which we included the estimated genomic breeding values (GEBVs) for the phenotypes additionally to the expression levels, originally proposed for these methods. We used PCIT to determine putative regulatory relationships based on significant associations between gene expression and GEBVs for each mineral amount. Then, RIF was adopted to determine the regulatory impact of genes and miRNAs expression over the GEBVs for the mineral amounts. We also investigated over-represented pathways, as well as pieces of evidences from previous studies carried in the same population and in the literature, to determine regulatory genes for the mineral amounts. For example, NOX1 expression level was positively correlated to Zinc and has been described as Zinc-regulated in humans. Based on our approach, we were able to identify genes, miRNAs and pathways not yet described as underlying mineral amount. The results support the hypothesis that extracellular matrix interactions are the core regulator of mineral amount in muscle cells. Putative regulators describe... Mostrar Tudo |
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Palavras-Chave: |
Expressão gênica. |
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Thesagro: |
Bos Indicus; Gado Nelore. |
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Thesaurus Nal: |
Cattle; Gene expression. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/215819/1/AP-Genetic-regulators-2020.pdf
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Marc: |
LEADER 02716naa a2200361 a 4500
001 2124802
005 2020-09-10
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1038/s41598-020-65454-7$2DOI
100 1 $aAFONSO, J.
245 $aGenetic regulators of mineral amount in Nelore cattle muscle predicted by a new co-expression and regulatory impact factor approach.$h[electronic resource]
260 $c2020
500 $aArticle: 8436.
520 $aMineral contents in bovine muscle can affect meat quality, growth, health, and reproductive traits. To better understand the genetic basis of this phenotype in Nelore (Bos indicus) cattle, we analysed genome-wide mRNA and miRNA expression data from 114 muscle samples. The analysis implemented a new application for two complementary algorithms: the partial correlation and information theory (PCIT) and the regulatory impact factor (RIF), in which we included the estimated genomic breeding values (GEBVs) for the phenotypes additionally to the expression levels, originally proposed for these methods. We used PCIT to determine putative regulatory relationships based on significant associations between gene expression and GEBVs for each mineral amount. Then, RIF was adopted to determine the regulatory impact of genes and miRNAs expression over the GEBVs for the mineral amounts. We also investigated over-represented pathways, as well as pieces of evidences from previous studies carried in the same population and in the literature, to determine regulatory genes for the mineral amounts. For example, NOX1 expression level was positively correlated to Zinc and has been described as Zinc-regulated in humans. Based on our approach, we were able to identify genes, miRNAs and pathways not yet described as underlying mineral amount. The results support the hypothesis that extracellular matrix interactions are the core regulator of mineral amount in muscle cells. Putative regulators described here add information to this hypothesis, expanding the knowledge on molecular relationships between gene expression and minerals.
650 $aCattle
650 $aGene expression
650 $aBos Indicus
650 $aGado Nelore
653 $aExpressão gênica
700 1 $aFORTES, M. R. S.
700 1 $aREVERTER, A.
700 1 $aDINIZ, W. J. da S.
700 1 $aCESAR, A. S. M.
700 1 $aLIMA, A. O. de
700 1 $aPETRINI, J.
700 1 $aSOUZA, M. de S.
700 1 $aCOUTINHO, L. L.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aGROMBONI, C. F.
700 1 $aNOGUEIRA, A. R. A.
700 1 $aREGITANO, L. C. de A.
773 $tScientific Reports$gv. 10, n. 1, p. 1-16, 2020
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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| Registros recuperados : 39 | |
| 2. |  | NUNES, W. A. G. de A.; SILVA, L. B. X. Resposta da cultura do milho a fósforo fornecido por composto orgânico elaborado a partir de bagaço de sorgo-sacarino. In: SEMINÁRIO INTERNACIONAL DE AGROECOLOGIA DA AMÉRICA DO SUL, 2.; JORNADA INTERNACIONAL DE EDUCAÇÃO DO CAMPO, 1.; SEMINÁRIO DE AGROECOLOGIA DE MATO GROSSO DO SUL, 6; ENCONTRO DE PRODUTORES AGROECOLÓGICOS DE MATO GROSSO DO SUL, 5.; SEMINÁRIO DE SISTEMAS AGROFLORESTAIS EM BASES AGROECOLÓGICAS DE MATO GROSSO DO SUL, 2., 2016, Dourados. Agroecologia e soberania alimentar: saberes em busca do bem viver: anais. Dourados: UFGD, 2016. Não paginado. Agroecol 2016. 1 CD-ROM. Publicado também em: Cadernos de Agroecologia, v. 11, n. 2, 2016.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 8. | | CONCENCO, G.; MOTTA, I. de S.; MELO, T. S.; SILVA, L. B. X. da; MARIANI, A. Ocorrência de plantas espontâneas em café solteiro ou consorciado com braquiária. Cadernos de Agroecologia, Porto Alegre, v. 10, n. 3, 2015. Edição dos Resumos do IX Congresso Brasileiro de Agroecologia e IV Seminário Estadual de Agroecologia, Belém, PA, set./out. 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 11. | | CONCENCO, G.; MARQUES, R. F.; MELO, T. S.; SILVA, C. J. da; STAUT, L. A.; SILVA, L. B. X. da. Infestação de plantas daninhas em cultivos de milho safrinha comparado a outras opções de inverno. In: SEMINÁRIO NACIONAL [DE] MILHO SAFRINHA, 13., 2015, Maringá. 30 anos de inovação em produtividade e qualidade. Maringá: ABMS, 2015.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 13. | | CONCENÇO, G.; TOMAZI, M.; MARQUES, R. F.; CHANDRA, S.; CHANDOLA, V.; MELO, T. S.; SILVA, L. B. X. da. Sustentabilidade do cultivo de mandioca em comunidades indígenas do Pantanal Brasileiro Research, Society and Development, v. 10, n. 1, p. e56010112070, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 15. | | MARQUES, R. F.; CORREIA, I. V. T.; MELO, T. S.; SILVA, L. B. X. da; LINHARES, L. T.; CARRARO, T. V.; CONCENCO, G. Alelopatia de extratos de sorgo-sacarino sobre capim-amargoso In: JORNADA DE INICIAÇÃO À PESQUISA DA EMBRAPA, 2015, Dourados. Resumos... Brasília, DF: Embrapa, 2015. JIPE 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 16. | | SILVA, L. B. X. da; MELO, T. S.; LINHARES, L. T.; CORREIA. I. V. T.; MARQUES, R. F.; CONCENCO, G.; SALTON, J. C. Interferência de plantas daninhas em diferentes sistemas de produção. In: JORNADA DE INICIAÇÃO À PESQUISA DA EMBRAPA, 2015, Dourados. Resumos... Brasília, DF: Embrapa, 2015. JIPE 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 17. | | MELO, T. S.; ALVES, M. E. dos S.; SILVA, L. B. X. da; LINHARES, L. T.; CORREIA, I. V. T.; MARQUES, R. F.; CONCENCO, G. Interações competitivas entre a cultura do milho e capim-branco. In: JORNADA DE INICIAÇÃO À PESQUISA DA EMBRAPA, 2015, Dourados. Resumos... Brasília, DF: Embrapa, 2015. JIPE 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 18. | | SILVA, L. B. X. da; MELO, T. S.; ALVES, M. E. dos S.; LINHARES, L. T.; CORREIA, I. V. T.; MARQUES, R. F.; CONCENCO, G. Interações competitivas da soja e capim-branco pelo método substitutivo de avaliação. In: JORNADA DE INICIAÇÃO À PESQUISA DA EMBRAPA, 2015, Dourados. Resumos... Brasília, DF: Embrapa, 2015. JIPE 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 20. | | CONCENÇO, G.; BRITO, G. G. de; FAGUNDES, P. R. R.; SCIVITTARO, W. B.; PARFITT, J. M. B.; MELO, T. S.; SILVA, L. B. X. da; DEUNER, S. Contribution for improvement of rice breeding programs through morphoanatomical traits. Journal of Agricultural Studies, v. 9, n. 2, p. 304-322, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: C - 0 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| Registros recuperados : 39 | |
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