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Registro Completo |
Biblioteca(s): |
Ebooks. |
Data corrente: |
01/02/2013 |
Data da última atualização: |
01/02/2013 |
Autoria: |
ADAMS, P. D.; SEDIVY, J. M. |
Afiliação: |
Peter D. Adams; John M. Sedivy. |
Título: |
Cellular Senescence and Tumor Suppression. |
Ano de publicação: |
2010 |
Fonte/Imprenta: |
Springer eBooks. |
Páginas: |
XIII, 272p. 25 illus., 5 illus. in color. With 1 4-color ins |
Descrição Física: |
digital. |
ISBN: |
9781441910752 |
DOI: |
10.1007/978-1-4419-1075-2 |
Idioma: |
Inglês |
Conteúdo: |
Telomere biology and biochemistry -- Short telomere-driven senescence -- Oncogene-induced senescence -- Stress-induced senescence -- Modulation of senescence by extracellular growth factors -- The senescent phenotype and its evolution -- Chromatin structure in senescent cells -- A comparison of senescence in mouse and human cells -- Tumor suppression -- Tissue aging -- Senescence as a potential therapeutic tool. .Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, showing that these cells can proliferate in vitro for about 55 population doublings before their proliferative capacity succumbs to irreversible proliferation arrest. Since those original observations, major advances in our understanding have come in several areas. We now know that several other triggers, in addition to proliferative exhaustion, can trigger the senescence program. One important class of senescence triggers, and a focus of this volume, are activated oncogenes in primary untransformed cells. There is now good evidence to indicate that senescence in response to this cue is a potent tumor suppressor mechanism, through its ability to block proliferation of incipient cancer cells. However, senescence is not simply a passive proliferation arrest that impacts only the senescent cell itself, but rather, senescent cells influence their environment and neighboring cells through an active secretory program. This secretory program appears to facilitate senescence as a tumor suppression process. Cellular Senescence and Tumor Suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions, with a particular emphasis on the role of senescence in tumor suppression. MenosTelomere biology and biochemistry -- Short telomere-driven senescence -- Oncogene-induced senescence -- Stress-induced senescence -- Modulation of senescence by extracellular growth factors -- The senescent phenotype and its evolution -- Chromatin structure in senescent cells -- A comparison of senescence in mouse and human cells -- Tumor suppression -- Tissue aging -- Senescence as a potential therapeutic tool. .Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, showing that these cells can proliferate in vitro for about 55 population doublings before their proliferative capacity succumbs to irreversible proliferation arrest. Since those original observations, major advances in our understanding have come in several areas. We now know that several other triggers, in addition to proliferative exhaustion, can trigger the senescence program. One important class of senescence triggers, and a focus of this volume, are activated oncogenes in primary untransformed cells. There is now good evidence to indicate that senescence in response to this cue is a potent tumor suppressor mechanism, through its ability to block proliferation of incipient cancer cells. However, senescence is not simply a passive proliferation arrest that impacts... Mostrar Tudo |
Palavras-Chave: |
Biomedicine; Cancer Research; Oncology; Pharmacology/Toxicology. |
Thesaurus Nal: |
human genetics; medicine; toxicology. |
Categoria do assunto: |
-- |
URL: |
https://dx.doi.org/10.1007/978-1-4419-1075-2
|
Marc: |
LEADER 02720nam a2200241 a 4500 001 1947626 005 2013-02-01 008 2010 bl uuuu u0uu1 u #d 020 $a9781441910752 024 7 $a10.1007/978-1-4419-1075-2$2DOI 100 1 $aADAMS, P. D. 245 $aCellular Senescence and Tumor Suppression.$h[electronic resource] 260 $aSpringer eBooks.$c2010 300 $aXIII, 272p. 25 illus., 5 illus. in color. With 1 4-color ins$cdigital. 520 $a<P>Telomere biology and biochemistry -- Short telomere-driven senescence -- Oncogene-induced senescence -- Stress-induced senescence -- Modulation of senescence by extracellular growth factors -- The senescent phenotype and its evolution -- Chromatin structure in senescent cells -- A comparison of senescence in mouse and human cells -- Tumor suppression -- Tissue aging -- Senescence as a potential therapeutic tool.</P>.<P>Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, showing that these cells can proliferate in vitro for about 55 population doublings before their proliferative capacity succumbs to irreversible proliferation arrest. </P> <P>Since those original observations, major advances in our understanding have come in several areas. We now know that several other triggers, in addition to proliferative exhaustion, can trigger the senescence program. One important class of senescence triggers, and a focus of this volume, are activated oncogenes in primary untransformed cells. There is now good evidence to indicate that senescence in response to this cue is a potent tumor suppressor mechanism, through its ability to block proliferation of incipient cancer cells. However, senescence is not simply a passive proliferation arrest that impacts only the senescent cell itself, but rather, senescent cells influence their environment and neighboring cells through an active secretory program. This secretory program appears to facilitate senescence as a tumor suppression process. </P> <P>Cellular Senescence and Tumor Suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions, with a particular emphasis on the role of senescence in tumor suppression. </P> 650 $ahuman genetics 650 $amedicine 650 $atoxicology 653 $aBiomedicine 653 $aCancer Research 653 $aOncology 653 $aPharmacology/Toxicology 700 1 $aSEDIVY, J. M.
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Registros recuperados : 15 | |
7. | | SOARES, J. P. G.; AROEIRA, L. J. M.; FONSECA, A. H. DA; SANAVRIA, A.; SILVA, J. B.; FAGUNDES, G. M. Produção organica de leite no Brasil: tecnologias para produção sustentável. In: Congresso Brasileiro de Raças Zebuínas, 8., / Simpósio Pecuária Tropical Sustentável, 2011, Uberaba. Anais...Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Gado de Leite. |
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9. | | SALGADO, F. P.; HONER, M. R.; ISHIKAWA, M. M.; MADUREIRA, R. C.; SOARES, C. O.; RIGO, L.; FONSECA, A. H. da. Detecção de anticorpos Ant-Borrelia burgdorferi em cães procedenes do Centro de Controle de Zoonoses de Campo Grande, Mato Grosso do Sul, Brasil. Revista Brasileira de Medicina Veterinária, v. 30, n. 2, p. 97-101, abr./jun. 2008.Tipo: Artigo em Periódico Indexado | Circulação/Nível: Nacional - B |
Biblioteca(s): Embrapa Agropecuária Oeste. |
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10. | | SALGADO, F. P.; HONER, M. R.; ISHIKAWA, M. M.; MADUREIRA, R. C.; SOARES, C. O.; RIGO, L.; FONSECA, A. H. da. Detecção de anticorpos anti-Borrelia burgdorferi em cães procedentes do Centro de Controle de Zoonoses de Campo Grande, Mato Grosso do Sul, Brasil. Revista Brasileira de Medicina Veterinária, Rio de Janeiro, v. 30, n. 2, p. 97- 101, abr./jun. 2008.Tipo: Artigo em Periódico Indexado | Circulação/Nível: Nacional - B |
Biblioteca(s): Embrapa Gado de Corte. |
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11. | | SOCOLOSKI, S. N. G.; CASTRO, B. G. de; CORDEIRO, M. D.; FONSECA, A. H. da; CEPEDA, M. B.; NICOLINO, R. R.; LOPES, L. B. Epidemiological investigation of Borrelia burgdorferi in horses in the municipality of Sinop-MT, Brazil. Tropical Animal Health and Production, v. 50, n. 4, p. 831-836, 2018. 6 p.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
Biblioteca(s): Embrapa Agrossilvipastoril. |
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12. | | BONADIMANN, S. N. G. S.; CORDEIRO, M. D.; BAUTISTA, J. L. R.; SILVA, J. B. da; NICOLINO, R. R.; FONSECA, A. H. da; LOPES, L. B. Serological and molecular detection of Theileria equi in horses from Sinop, Mato Grosso state, Brazil. Revista Brasileira de Ciência Veterinária, v. 28, n. 3, p. 156-161, 2021. Título em português: Detecção sorológica e molecular de Theileria equi em equinos oriundos de Sinop, Mato Grosso, Brasil.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
Biblioteca(s): Embrapa Agrossilvipastoril. |
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13. | | CAMPOS, S. D. E.; CUNHA, N. C. da; MACHADO, C. S. C.; SOUZA, T. V. T. de; FONSECA, A. B. M.; PINTER, A.; FONSECA, A. H. da; ALMOSNY, N. R. P. Circulação de Rickettsias do Grupo da Febre Maculosa em cães no entorno de Unidades de Conservação Federais do estado do Rio de Janeiro: evidência sorológica e fatores associados. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 11, p. 1307-1312, novembro 2017. Título em inglês: Spotted Fever Group Rickettsiae in dogs at the surroundings of Conservation Units in the state of Rio de Janeiro: serological survey and associated factors.Biblioteca(s): Embrapa Unidades Centrais. |
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14. | | SILVA, J. B. da; LOPES, C. T. de A.; SOUZA, M. G. S. de; GIBSON, A. F. B.; VINHOTE, W. M. de S.; FONSECA, A. H. da; ARAUJO, F. R.; BARBOSA-NETO, J. D. Detecção sorológica e molecular de Anaplasma marginale em búfalos na Ilha de Marajó, Pará1. Pesquisa Veterinária Brasileira, v. 34, n. 1, p. 11-14, jan., 2014Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Gado de Corte. |
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15. | | TEMBUE, A. A. M.; SILVA, J. B. da; SILVA, F. J. M. da; PIRES, M. S.; BADANI, C. D.; SOARES, C. O.; MASSARD, C. L.; FONSECA, A. H. da. Seroprevalence of IgG antibodies against Anaplasma marginale in cattle from south Mozambique Revista Brasileira de Parasitologia Veterinária, v. 20, n. 4, p. 318-324, out-dez. 2011. 20Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
Biblioteca(s): Embrapa Gado de Corte. |
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